Study of Inclusion Complex of Baclofen® Analogues with β-Cyclodextrin and Determination of its Stability Constant by UV-Visible Spectroscopy

Assia Keniche1,2,*, Si Said Mohammed El-Amine2 and Joseph Kajima Muengi3

1University Centre of Maghnia, Tlemcen, Algeria

2Laboratoire de Chimie Organique, Substances Naturelles et Analyses (COSNA), University of Tlemcen, Tlemcen, Algeria

3Faculty of Sciences, University of Tlemcen, Tlemcen, Algeria

*To whom correspondence to be addressed: E-mail: [email protected]

Abstract

This work reports the interactions of an analogue of baclofen® (A-BF) with β-cyclodextrin and the calculation of stability constant (K) of inclusion complex using UV-visible spectroscopy. 0.1 M solutions of a steady concentration of baclofen® and varying concentrations of (β-cyclodextrin) were prepared in water. The final β-cyclodextrin solutions concentrations ranged between 0.0 and 0.00019 M. Each solution was examined at 202 nm. Absorbances were recorded and plotted against cyclodextrin concentrations. From the plot, the concentrations of both free and bound baclofen® and free β-cyclodextrin were calculated by using the Bensi-Hildebrand method. Then stability constant K was calculated. The magnitude of the stability constant is discussed and the stoichiometry of inclusion complex was determined by means of Job's plot.

Keywords

β-Cyclodextrin, Inclusion complex, Baclofen® analogues, Alcoholic

  
 
  • Asian J. Mat. Chem. /
  •  2018 /
  •  3(3) /
  •  pp 42-46
  • DOI:10.14233/ajmc.2018.AJMC-P55